Table of Contents

February  2023

  • Volume 60
  • Issue 2
  • Page Nos. 92

ISSN: 0019-462X (print)

Editorial

Need for “Networking” among “Cross Disciplinary Scientists”

PAGE 5-6

Dear Reader,

Indians should be proud of “India”. We have grown from a tiny group in the “sixties” to what we are today through “IDMA” (Indian Drug Manufacturers’ Association), through intense “networking” and “knowledge exchange” between pharmaceutical and allied p...

Dr. Gopakumar G. Nair

Editor

Indian Drugs

Review Article

SULFOXIDES AND SULFONES: REVIEW

PAGE 7-14

It has been established that sulfoxide with sulfones have distinct pharmacological effects. Commodity compounds like sulfoxide and sulfones find widespread use in many chemical disciplines. This is why organic chemists find the synthesis of sulfoxide and sulfones so interesting. In the process of...

Satwashila S. Kadama *, Niranjan S. Mahajanb, Pankaj A. Jadhavc and Shashikant C. Dhawaled

Original Research Articles

2D QSAR ANALYSIS OF CARBONITRILE BASED INHIBITORS OF CATHEPSIN S AS POTENTIAL ANTIRHEUMATIC AGENTS

PAGE 15-35

2D QSAR has been performed on a series of pyridine carbonitrile and trifluoromethyl phenyl derivatives. 53 compounds were divided into training and test sets out of which 37 compounds generated a final QSAR model. The most significant model with n = 37, r = 0.916, r2 = 0.762, r2 cv = 0.759, s val...

Sneha Kushwahaa *, Sarvesh K. Paliwalb and Divya Niranjanc

TOPICAL DELIVERY OF PAPAIN FOR MANAGEMENT OF PSORIASIS: FORMULATION DEVELOPMENT AND ASSESSMENT OF ANTI-PROLIFERATIVE ACTIVITY USING HaCaT CELL LINE

PAGE 36-43

The study was aimed at developing topical gel containing papain as the drug and assessing its antipsoriatic activity. Carbopol was used as the polymer and drug-excipient compatibility was ascertained by infrared spectroscopy (Fourier transform) and differential scanning calorimetry. All prepared ...

Richika Bansala , Ram B. Sharmab and Shweta Agarwala *

ISOLATION, CHARACTERIZATION AND EVALUATION FOR ANTIPLASMODIAL ACTIVITY OF EXTRACTED CONSTITUENTS FROM CAESALPINIA CRISTA LINN SEEDS

PAGE 44-49

The present work deals with extraction, isolation and characterization of phytoconstituents from seeds of Caesalpinia crista Linn and the study of their antiplasmodial activity. The phytoconstituents were extracted using soxhlet apparatus and separated by column chromatography. Structural elucida...

Swapna Reddy M.a *,b and Ramya Kuber B. b

DETERMINATION OF FOURTEEN PREFERRED ELEMENTAL IMPURITIES EMPLOYING ICP-MS AND MICROWAVE ACID DIGESTION APPROACH IN PARENTERAL OFLOXACIN SAMPLES

PAGE 50-59

The method of “Inductively Coupled Plasma Mass Spectrometry” (ICP-MS) may be interpreted as a trend in pharmaceutical determination of elemental impurities. The development of a specific process that is precise for all elemental impurities, however, is still a task. The ICP-MS technique using...

Gopikrishna Yenduria and Srinivasu Navuluria *

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ROSUVASTATIN AND TENELIGLIPTIN IN THEIR SYNTHETIC MIXTURE

PAGE 60-69

A simple, fast and accurate Reverse Phase High Performance Liquid Chromatography method has been established and validated for estimation of rosuvastatin and teneligliptin in their synthetic mixture. The chromatographic separation was achieved on Agilent Inertsil Octa Decyl Silane (ODS) C18 (250 ...

Minakshi M. Dhorua *, Maitri P. Parikha , Krunal K. Detholiab and Pathik J. Patelc

PREPARATION, DEVELOPMENT AND PHARMACOLOGICAL EVALUATION OF VRUDHADARAK RASAYANA IN MEMORY DEFICIT EXPERIMENTAL ANIMALS

PAGE 70-79

Vrudhadarak rasayan has been prepared in accordance with ayurvedic literature. Specifically, this formulation is based on Vrudhadarak rasayan developed by Chakradatta. The effect of Vrudhadarak rasayan on memory was evaluated using pre-clinical animal table with special reference to retention of ...

Sampada V. Bendea * and Arati P. Dubewara

Short Communications

DEVELOPMENT, OPTIMIZATION AND VALIDATION OF HPLC METHOD FOR ASSAY AND DISSOLUTION TESTING OF FUROSEMIDE TABLET FORMULATION UTILIZING DESIGN OF EXPERIMENT APPROACH

PAGE 80-82

A robust HPLC method was developed and validated for the quantitative estimation of furosemide tablet and dissolution testing. The optimization of chromatographic conditions (% organic phase, flow rate and pH of aqueous phase) was done using the Box-Behnken experimental design. The creation of a ...

Srushti Shaha , Mrunali R. Patela and Rashmin B. Patela *

SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF SULPHACETAMIDE SODIUM AND PREDNISOLONE ACETATE IN OPHTHALMIC FORMULATION

PAGE 83-85

A simple, precise, accurate, and rapid derivative spectrophotometric approach for the simultaneous quantification of sulfacetamide sodium (SUL) and prednisolone acetate (PRE) in the combined dosage form has been established and validated. The wavelengths selected for analysis are 230 nm (ZCP of S...

Satish A. Patela and Dharmendrasinh A. Bariab*

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