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After introduction of a new natural or synthetic chemical entity as a drug, the focus of research has always shifted to the modification of this chemical entity with the objective of improving ADMET properties, formulations for its efficient delivery, solubility, stability, ...

Cannabis, a diverse compounded plant with a rich cultural and scientific history, has garnered significant attention due to its therapeutic and medicinal potential. The plant’s main active compounds, phytocannabinoids, notably Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), play important...

This paper deals with the design, synthesis and biological evaluation of new pyrazolyl indole derivatives including azo compounds and Mannich salts. The work of this research could lead to potentially useful analgesic and anti-inflammatory agents. Utilizing the synthetic route illustrated in Fig....

Curcumin is a natural polyphenol known to exhibit multiple therapeutic effects. Methods for the synthesis of curcumin employ complexing of acetylacetone with boron compounds, which protects the active methylene group. As the reactions are not optimal with boron-based complexes, alternative ...

This study investigates the link between cigarette smoke, specifically benzo(a)pyrene (BaP), and cerebral palsy, focusing on BaP’s neurotoxicity. It also examines the neuroprotective potential of hesperidin, a citrus-derived compound, by assessing its binding affinity with the β4 subunit of ...

In order to increase deferasirox’s (DEF) solubility and dissolution rate, the study aims to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS). The impact of concentrations of oil and surfactant on emulsification and in vitro drug release was investigated using an oil, ...

The current investigation studied and verified an accurate Ultra performance liquid chromatography mass spectroscopy/ mass spectroscopy technique for the high-throughput detection of pomalidomide in human plasma with celecoxib as an internal standard. Chromatographic studies were carried out on ...

The study aims to examine the blood glucose-lowering effects of fresh Coccinia grandis fruit and assess how drying affects its antidiabetic potential. Additionally, the study seeks to determine the optimal administration procedure to maximize its antidiabetic efficacy. An oral glucose tolerance ...

Traditional medicinal plants have long been used in people’s healthcare regimens to treat a wide range of ailments. The ancient medicinal plant Embelia ribes Burm. (E. ribes) has potential for a wide range of pharmacological activities that are linked to embelin, a natural dihydroxy ...