ABSTRACT

Vrudhadarak rasayan has been prepared in accordance with ayurvedic literature. Specifically, this formulation is based on Vrudhadarak rasayan developed by Chakradatta. The effect of Vrudhadarak rasayan on memory was evaluated using pre-clinical animal table with special reference to retention of memory. The present study provides details of preparation of Vrudhadarak rasayan and enlists its analytical characterization along with preclinical activity related to retention of memory in Wistar rats. The developed Vrudhadarak rasayan was evaluated for its organoleptic characteristics and analytical parameters. Furthermore, Vrudhadarak rasayan revealed its memory retention activity through two animal tables, namely working memory with “Y-maze” table and Spatial memory with “Y-maze-novel arm” table. Furthermore, in vivo table of Vrudhadarak rasayan showed prominent enhancement in retention of memory (*p<0.05) as compared to standard drug donepezil. In conclusion, the Vrudhadarak rasayan shows a promising activity in memory enhancement and/or retention of memory in rats. This research can be helpful in clinical testing of Vrudhadarak rasayan either adjuvant of monotherapy for treatment of Alzheimer’s disease.