Table of Contents

March  2022

  • Volume 59
  • Issue 3
  • Page Nos. 80

Editorial

CHANGES IN THE NATURE OF PHARMACEUTICAL R&D PROGRAMS

PAGE 5-6

Dear Reader,

The global innovation index 2021 ranked INDIA 48th among 131 countries. This low ranking assigned to India reflects the quality of our research programs. In the realm of pharmaceuticals, the Indian industry has excelled in the manufacture of low value generic products, howeve...

Dr. George Patani

Associate Editor

Indian Drugs

Review Article

LAT1: A POTENTIAL CEREBROVASCULAR TARGET TO BREACH BBB

PAGE 7-17

Central nervous system (CNS) is always an area of thrust where continuous efforts are required to achieve targeted drug delivery. The blood brain barrier (BBB) is the chief interfering element in the development of effective neurotherapeutics and efficient drug delivery to the CNS. Large neutral ...

Meenakshi Dhanawata*, Sumeet Guptab, Rina Dasa and Dinesh K. Mehtaa

Original Research Articles

SYNTHESIS, COMPUTATIONAL AND IN VITRO ANTI-DIABETIC STUDIES OF NOVEL THIAZOLIDIN-4-ONES DERIVATIVES

PAGE 18-24

A new series of thiazolidin-4-ones (T1-10) were synthesized by the reaction of Schiff’s bases(Ta-j) and thioglycolic acid in dioxane medium in the presence of anhydrous zinc chloride as a catalyst. All the newly synthesized compounds were characterized by IR, 1H-NMR and mass spectral...

Banylla F. D. Gatphoha , Natasha N. Aggarwala , Vijaykumar M.a and Revanasiddappa B. C.a *

FORMULATION AND EVALUATION OF FLOATING MICROSPHERES OF LANSOPRAZOLE

PAGE 25-30

Lansoprazole has a short half-life and it gets absorbed only in the proximal part of the small intestine. Floating microspheres of such a drug floats on the stomach contents and releases the drug slowly for longer periods of time. Thus, to overcome the problem like short half-life and to enhance ...

Archana N. Barhatea*, Tanuja S. Shindea and Pratiksha S. Rampurea

PHYTOCHEMICAL ANALYSIS AND IN VITRO GENOTOXICITY, CYTOTOXICITY, ANTIOXIDANT, ANTIMICROBIAL, ANTIOBESITY ACTIVITY OF MORINDA TINCTORIA ROXB.

PAGE 31-40

The medicinal plant Morinda tinctoria Roxb. is used in the treatment of various diseases traditionally. Report on bioactive evaluation of M. tinctoria Roxb. has led us to the phytochemical examination of M. tinctoria leaves. Our objective was to isolate compounds form M...

Deepti Kollia , Karteek Rao Amperyanib and Umadevi Parimib*

SIMULTANEOUS DETERMINATION OF BIOACTIVE CONSTITUENTS IN GARCINIA MORELLA USING UPLC-Q-TOF-MS

PAGE 41-46

A simple, precise and robust UPLC-Q-TOF-MS method was developed for the quantification of four marker compounds, namely citric acid derivative, iso garcinol, garcinol and garcimultiflorone-A in Garcinia morella, in order to study the fragmentation pathways of four marker compounds. The d...

Rathnakar Nathia * and Sankar D.Ga

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF LORNOXICAM AND TOLPERISONE HYDROCHLORIDE IN BULK DRUG AND COMBINED DOSAGE FORM

PAGE 47-53

A Reverse Phase High Performance Liquid Chromatographic method was developed and validated for the simultaneous estimation of lornoxicam and tolperisone hydrochloride in bulk drug and its combined dosage form. Chromatographic separation was carried out isocratically by reverse phase water enable ...

Tushar H. Patela , Umang H. Shaha , Manan A. Ravalb and Samir G. Patel a*

SCREENING THE INFLUENCE OF DILTIAZEM ON ORAL ANTIDIABETIC AGENTS IN EXPERIMENTAL ANIMALS

PAGE 54-61

The main aim of this study was to assess the possibility of potential interaction of repaglinide and rosiglitazone with diltiazem. A calcium channel blocker, diltiazem potentially inhibits CYP3A4 and 2C8. Important to note, both drugs meglitinide and thiazolidinediones are actively metabolised by...

Suresh D. K.a *, Akshay Vibhutea and Imad Uddin MDb

COSMETICS USAGE HABITS AND EFFECT ON HEALTH SEEKING BEHAVIOR AMONG JORDANIAN WOMEN

PAGE 62-66

Cosmetics are composed of a mixture of chemicals and natural compounds, and most adverse effects occur due to sharing the same products and using the makeup after the expiry date. This behavior tends to increase the side effects of cosmetics due to pathogenic infections. Lack of awareness and kno...

Abu Hajleh Maha N.a *, AL-Samydai Alib, AL-Samydai Mahmud Jasimc , Al-Somaiday Humam M.d, Othman Yousif Rudainae and Al-Dujaili Emad A. S.f

Short Communications

GC/MS ANALYSIS OF ADHATODA VASICA LEAF AND FLOWER

PAGE 67-68

Adhatoda vasica is a medicinal plant in use since ancient times. It is a recommended bronchodilator and thus useful in the treatment of asthma. In the present research work, GC/MS analysis of volatile oil isolated from leaves and flowers of A. vasica was carried out. It...

Supriya Agnihotria *, Sharad Wakodeb and Mohd Alic

COMBINED MIXTURE DESIGN IN OPTIMIZATION OF EXTRACTION SOLVENT FOR ASSAY TEST OF ETHYL CELLULOSE COATED TRAMADOL TABLETS

PAGE 69-72

The aim of the present study was to apply combined mixture design to optimize extraction solvent composition to enhance filtration volume and recovery of assay test sample with ethyl cellulose coated tablets. Solvent composition, centrifugation time and additional filtration step were evaluated a...

Sudheer B. Kollaa,b*, Madhusudhan R. Vallabhanenia , Srinivasa B. Puttuguntac and Yaswanth Pakyalab

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