ABSTRACT

The influence of microwave technology and modified gum kondagogu (MGK) on the in vitro dissolution rate of a poorly - water soluble drug repaglinide (RG) was studied. Solid dispersions were prepared using gum kondagogu (GK) & MGK as a carrier by microwave method. Microwave generated solid dispersions with MGK exhibited remarkable improvement in solubility and dissolution rate compared to that of pure RG. In conclusion, microwave method together with MGK as a potential carrier could be considered as simple, efficient and solvent free promising alternative method to prepare solid dispersions.