ABSTRACT

The effect of various concentrations of chitosan as a polymer was investigated for the transdermal delivery of atenolol across human cadaver skin by using dimethylsulfoxide as a penetration enhancer. Atenolol-chitosan matrix type patches were formulated using different polymer concentrations. Atenolol at a fixed concentration of 10 mg was added in polymer and dibutyl phthalate, 30% w/w of polymer, was added as a plasticizer. All the transdermal patches were evaluated for thickness, weight variation, folding endurance, breaking force, and percent moisture content. The comparative study of release kinetics with different polymer ratios showed that the patch containing drug polymer ratio 1:7 had maximum release of drug (81.92%) and all its physicochemical parameters were within the acceptable limit.