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Analgesic and Anti-inflammatory Activity of Methanolic Extract from Jatropha Curcas (Euphorbiaceae) Leaves on Experimental Animals

Chandra P.*, Sachan N., Yadav R., Kishore K. and Ghosh A. K.

School of Pharmaceutical Sciences, IFTM University, Lodhipur Rajput, Delhi Road (NH-24) Moradabad 244102. Uttar Pradesh, India.





The present study evaluates the analgesic and anti-inflammatory activities of the methanolic extract from Jatropha curcas (Euphorbiaceae) leaves to provide experimental evidence for its traditional use. Investigations on the analgesic effects and anti-inflammatory activities of J. curcas were carried out by utilizing the different animal models. It has been shown that the methanolic extract from Jatropha curcas leaves significantly increased pain threshold and reduced writhing response as well as inhibited the increase in vascular permeability. Also, it significantly decreased the carrageenan-induced rat paw edema. The results show that the methanolic extract from Jatropha curcas leaves have both central and peripheral analgesic activities and as anti-inflammatory effects, supporting the traditional application of this herb in treating various diseases associated with inflammation and pain.

Year 2013 | Volume No. 50 | Issue No.8 | Page No. 32-38
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