ABSTRACT

Thiadiazoles are synthesized by using aromatic acids and thiosemicarbazide. Schiff base reaction is followed and then thiadiazolotriazole derivatives are prepared by using hydrazine hydrate, isoniazid and unhydrous FeCl₃. All the synthesized compounds were characterized by IR, 1H-NMR and CHN analyses. All the compounds were evaluated for antibacterial, antifungal & antitubercular activity. Compounds A₁,B₁, C₁ and C₄ have shown promising antibacterial activity, compounds A₃, A₄, B₄, C₂ and C₄ have exhibited excellent antifungal activities, while compounds A₂, A₄, B₂, B₄, C₂ and C₄ showed anti-tubercular activity.