Article Details

TECHNIQUES AND ALGORITHMS FOR STRUCTURE-BASED VIRTUAL SCREENING (SBVS): AN OVERVIEW

Raksha K. Raoa *, Somdatta Y. Chaudharia , Shailaja B. Jadhava , Pravin D. Chaudharib and Ujwala B. Yedakea

a Department of Pharmaceutical Chemistry, Progressive Education Society’s Modern College of Pharmacy, Nigdi, Pune – 411 044, Maharashtra, India

b Department of Pharmaceutics, Progressive Education Society’s Modern College of Pharmacy, Nigdi, Pune – 411 044, Maharashtra, India

* For Correspondence: E-mail: raksharao9598@gmail.com

 

https://doi.org/10.53879/id.61.01.13346


ABSTRACT

Today, the world of science is constantly challenged with new genomics, which in turn is responsible for new disease-causing targets. Hence, there is a need for developing drugs acting against such targets. Computational methods are proving to be a mainstay in the drug discovery process, mainly through virtual screening. This review discusses about the recent advancements in structure-based drug design with reference to Virtual Screening along with its procedures from ligand preparation and protein preparation, docking, scoring function, databases, and virtual (VS) algorithms. Application of Structure-based VS in combination with other virtual screening techniques has also been highlighted in this review.

Year 2024 | Volume No. 61 | Issue No.1 | Page No. 7-17
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