Article Details

PREFORMULATION STUDIES AND PROSPECTIVE VALIDATION OF UV-SPECTROPHOTOMETRIC METHOD OF AMOXICILLIN TRIHYDRATE

Prarthna Lakheraa, Sonia Narwalb and Minkal Tutejab*

a Department of Pharmaceutics, Gurugram Global College of Pharmacy, Farrukh Nagar– 122 506, Haryana, India

b Department of Pharmacy, Panipat Institute of Engineering and Technology, 70, Milestone GT Road, Patti Kalyana, Samalkha,Panipat-132 102, Haryana, India

For Correspondence: E-mail: drminkal.pharmacy@piet.co.in

 

https://doi.org/10.53879/id.61.05.14444


ABSTRACT

The current study was embarked upon to evaluate and assess the physicochemical characteristics of amoxicillin trihydrate. The determination and validation of UV-spectrophotometric for amoxicillin trihydrate was included in the study. The different physical characteristics used in preformulation, including solubility, FTIR, loss on drying, melting point, pH, flow qualities, moisture content and partition coefficient, were carefully evaluated and scrutinized. The proposed methods of analysis for amoxicillin trihydrate provide a simple, accurate, and reliable way of analyzing salivary fluid in a simulated buffer solution (pH 6.8) employing a UV spectrophotometer. The UV spectrophotometric method for amoxicillin trihydrate was developed and validated in salivary fluid simulated at pH 6.8. The intraday and interday RSD values both being less than 2 demonstrated that the method is accurate. The recovery study of drug obtained implies the robustness and durability of the method.

Year 2024 | Volume No. 61 | Issue No.5 | Page No. 52-58
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