Article Details

FORMULATION AND EVALUATION OF β-SITOSTEROL LOADED NIOSOMES FOR ENHANCED ANTIDIABETIC ACTIVITY: A POTENTIAL ALTERNATIVE IN TYPE 2 DIABETES MANAGEMENT

Priya Tiwaria * and Rajat Srivastavab

a Department of Pharmaceutics, Moradabad Educational Trust Group of Institutions, Faculty of Pharmacy, MIT Campus, Moradabad-244 001, Uttar Pradesh, India

b Department of Pharmaceutics, Shambhunath Institute of Pharmacy, Jhalwa, Prayagraj-211 015, Uttar Pradesh, India

For Correspondence: E-mail: tiwari93priya@gmail.com

 

https://doi.org/10.53879/id.61.05.14555


ABSTRACT

Niosomes, vesicles formed by non-ionic surfactants, offer advantages in drug delivery by enhancing solubilization and encapsulating both lipophilic and hydrophilic drugs. This study focuses on β-sitosterol-loaded niosomes designed to protect its anti-diabetic properties. Formulated with Span™ 60, Span™ 80 and cholesterol, the niosomes showed high entrapment efficiency (90%) and favorable release kinetics. Stability studies confirmed their robustness in various conditions. In vivo experiments demonstrated significant improvements in body weight and blood glucose levels in diabetic rats. The optimized formulation (NF8) exhibited controlled release and substantial antidiabetic activity, suggesting its potential as an effective treatment for type 2 diabetes mellitus.

Year 2024 | Volume No. 61 | Issue No.5 | Page No. 45-51
Recent Issue
Current Issue
Quick Contact