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A REVIEW IN CURCUMINOIDS: CHEMISTRY, ANTICANCER ACTIVITY AND FUTURE PROSPECTS

Pranjali Mishraa , Muskan Srivastava , Yashveer Gautama *, Monal Singha , Neeraj Vermab, Deepak S. Kapkotic , Shailendra P. Singhb, Anil K. Singhd and Devendra P. Raoe

a Department of Chemistry, Pandit Prithi Nath (PG) College, Kanpur - 208 001, Uttar Pradesh, India

b Department of Zoology, Pandit Prithi Nath (PG) College, Kanpur - 208 001, Uttar Pradesh, India

c CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow - 226 015,Uttar Pradesh, India

d Department of Botany, Pandit Prithi Nath (PG) College, Kanpur - 208 001, Uttar Pradesh, India

e Department of Chemistry, Dayanand Anglo-Vedic (PG) College, Kanpur - 208 001, Uttar Pradesh, India

For Correspondence: E-mail: yashveergautam_kn04@csjmu.ac.in

 

https://doi.org/10.53879/id.61.05.14041


ABSTRACT

Curcumin is a biologically active phytochemical which manifests therapeutic activities in numerous health conditions, including cancer. Several curcuminoids obtained naturally and synthesized artificially also showcase anti-cancer and anti-tumorigenic effects. However, its water insolubility poses difficulties in its application to biological systems, lowering its availability in living tissues, which can be overcome by using various micro-encapsulation and nano-formulations of curcumin. When used in combination with other chemotherapeutic drugs, curcumin enhances the anti-carcinogen potential and reduces the side effects induced via chemotherapy. Structural modelling of basic pharmacophores of curcumin can enhance its biological and pharmacokinetic properties, as revealed by structure-activity relationship studies of curcumin. Various clinical trials of curcumin have proven its worth as an anti-neoplastic agent in humans, with minimal side effects. Its mechanism of action involves blockage of cell-signalling pathways and cellular enzymes, promotion of immunomodulatory effects and induction of programmed cell death in cancerous cells. Curcumin is an interesting molecule with diverse effects on various diseases, but its absolute potential has yet to be reached. Hence, more in-depth studies and clinical trials are needed. This review outlines curcumin’s chemical properties and summarizes its anti-cancer and pharmacokinetic potential.

Year 2024 | Volume No. 61 | Issue No.5 | Page No. 7-23
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