ABSTRACT

Mitochondrial dysfunction as a virtue of oxidative stress leads to neurodegeneration. The neurotoxin rotenone, is widely used to induce mitochondrial dysfunction and hence evaluate the neuroprotective action of a sample drug. For this study and comparison, the hexane extract, chloroform extract, ethyl acetate extract and ethanol extract of the weed Portulaca quadrifida (Portulacaceae) were selected to study and compare the neuroprotective activity in rat brain synaptosomes.