ABSTRACT

Amlodipine is a BCS (biopharmaceutical Classification System) class I drug with high permeability and high solubility. It has a long half-life of 30-50h. It is a suitable model drug for formulating orodispersive tablets, as the orodispersive tablets can release the drug immediately. thus, formulation of amlodipine into orodispersible tablets will help in improved delivery of the drug at a faster rate. to achieve this, the orodispersive tablets were prepared by sublimation technique and the concentration of the sublimating agents was optimized by central composite design. based on the results, it was concluded that camphor and thymol when used at optimum concentrations can be used in the formulation of orodispersive tablets, the drug delivery systems for drugs with long half-life. they are potential delivery systems to improve palatability also for model drugs like amlodipine.