ABSTRACT

The use of microemulsion as a delivery system for improving take-up across the nasal mucosa is cur-rently being studied. A mucoadhesive polymer is added to help extend the retention time on the mucosa.The primary goal of the current research was to create a nano-formulation of amisulpride with the intention of increasing the drug’s permeability and protecting it with a biocompatible lipid content, avoiding first-pass metabolism and efflux mechanisms, and selecting the route of administration to deliver amisulpride to the brain or CNS to increase the bioavailability of amisulpride at the targeted site of Schizophrenia. For calculating the percentage of transmittance, the release profile, and the levels of amisulpride in the brain and plasma, appropriate analytical methods were chosen, developed and validated. The results revealed that the residence time of me (microemulsion) was enhanced by the mucoadhesive agent and that a targeted site of action was achieved