Article Details

HYDROXYPROPYL CELLULOSE-CARBOPOL AND HYDROXYPROPYL CELLULOSE -NOVEON COMPOSITE MOUTH DISSOLVING FILMS OF AMBROXOL HYDROCHLORIDE

Avinash B. Gangurdea , Suhas K. Khairnara * and Vinod A. Bairagia

a Department of Pharmaceutics, KBHSS Trusts Institute of Pharmacy, Malegaon, Nasik – 423 105, Maharashtra, India

*For Correspondence: E-mail: suhaskhairnar800@gmail.com

 

https://doi.org/10.53879/id.60.08.13041


ABSTRACT

Ambroxol hydrochloride is a choice of drug in acute and chronic lung infections. In the COVID-19 situation, ambroxol played a crucial role in treating bronchitis and potentiating, the effect of antibiotics in lung infections. In the present study, a patient-friendly drug delivery system of ambroxol hydrochloride was prepared by solvent casting method to produce better mechanical strength in the film. To impart better mechanical strength without affecting disintegration and dissolution, composite films of hydroxypropyl cellulose - Carbopol-981NF and hydroxypropyl cellulose – Noveon-AA1 were developed and evaluated. Nine formulations were prepared using varying levels of film formers. The evaluated film formulations were in folding endurance range 32±2.00 to 92±8.05, tensile strength range 27.51±1.22 to 130.32± 0.98 g cm-2, % elongation range 14.12±0.32 to 26.54±0.08 and disintegration time range 54±1.42 to 114±1.52 seconds, and more than 90% drug dissolution occurred within 5 min. All the prepared formulations showed compatibility between ambroxol hydrochloride and ingredients of film.

Year 2023 | Volume No. 60 | Issue No.8 | Page No. 56-62
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