ABSTRACT

The transdermal drug administration system represents a potent substitute for administering medications orally and is also designed to offer a substitute for hypodermic injections. Presently, three generations of penetration enhancer to permeate through skin are available 1^st Generation embraces chemical approaches and pertain to augment the efficacy of the drug transferred across the integral skin, 2^nd generation encompasses physical permeation technologies and 3^rd generation consists of microneedle and needleless penetration enhancers. There is renewed interest in transdermal drug delivery. This review focuses on some existing novel approaches and the additive upshot of techniques for increasing the permeation of drugs via skin penetration. By using the right methods, drug carriers, or certain chemical agents, it is important to cause the stratum corneum to change physically or biomolecularly.