Article Details

DESIGN, SYNTHESIS AND EVALUATION OF N-(BENZO[D]THIAZOL-2-YL)-2-OXO2H-CHROMENE-3-CARBOXAMIDE DERIVATIVES AS POTENTIAL ANTIOXIDANT AND ANTIBACTERIAL AGENTS

Ranjit V. Gadhavea *, Sachin S. Khadea , Yogita S. Ozardea , Somdatta Y. Chaudharib, Arti G. Swamia and Mukesh K. Meenac

a School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Pune-411 038, Maharashtra, India

b Department of Pharmaceutical Chemistry, PES’s Modern College of Pharmacy, Nigdi, Pune-411 044, Maharashtra, India

c Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur-313 001, Rajasthan, India

* For Correspondence: E-mail: ranjitgadhave@gmail.com

 

https://doi.org/10.53879/id.59.10.13222


ABSTRACT

This research is focused on designing, synthesis and biological evaluation of a series of coumarin based benzothiazole derivatives. The ligands were identified by docking study for antioxidant and antibacterial potential using target proteins PDB:4H1J and PDB:3G75, respectively. The target molecules were synthesized as a series of substituted N-(benzothiazol-2-yl)-2-oxo-chromene-3-carboxamides (7a–h) by condensation of substituted benzo[d]thiazol-2-amines with in situ synthesized substituted 2-oxo-2H-chromene-3-carbonyl chlorides. Infrared spectroscopy and 1 H- nuclear magnetic resonance spectra were used to characterize the synthesized molecules. In vitro antioxidant activity of compounds was evaluated by DPPH and H2 O2 radical scavenging assays. Antibacterial potential of compounds was evaluated using well diffusion method against Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853). Among synthesized derivatives, 7a showed good antioxidant potential whereas 7f showed antibacterial activity, which might be employed as lead molecules for future investigation for respective activities.

Year 2022 | Volume No. 59 | Issue No.10 | Page No. 20-29
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