a Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical, Sciences of Nitte -Deemed to be University, Paneer, Deralakatte, Mangalore-575 018, Karnataka, India
* For Correspondence: E-mail: revan@nitte.edu.in
https://doi.org/10.53879/id.59.03.12584
ABSTRACT
A new series of thiazolidin-4-ones (T1-10) were synthesized by the reaction of Schiff’s bases(Ta-j) and thioglycolic acid in dioxane medium in the presence of anhydrous zinc chloride as a catalyst. All the newly synthesized compounds were characterized by IR, 1H-NMR and mass spectral data and studied for in vitro antidiabetic activity. Most of the synthesized derivatives showed promising antidiabetic activity. This work indicates that the presence of the -OH group attached to the ring may be responsible for the activity. The new compounds were subjected to in silico analysis.
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