Article Details

SYNTHESIS, SPECTRAL STUDIES AND BIOLOGICAL ACTIVITY OF SOME IMIDAZO [2, 1-B] [1, 3, 4] THIADIAZOLE DERIVATIVES

Satvir Singha *, Divya Bhandaria , Monika Guptab, Chamanpreet Kaurb, Anju Ranib and Sunita Devib

a Department of Pharmaceutical Chemistry, University Institute of Pharmaceutical Sciences, Chandigarh University, Gharuan, Mohali– 140 413, Punjab, India

b Department of Pharmaceutical Chemistry, Amar Shaheed Baba Ajit Singh Jujhar Singh College of Pharmacy, Bela, Ropar-1401 11, Punjab, India

*For Correspondence: E-mail: divya.pharma@cumail.in

 

https://doi.org/10.53879/id.59.01.12612


ABSTRACT

Benzoic acid substituted imidazo[2,1-b][1,3,4]thiadiazoles were synthesized using appropriate reaction scheme. The synthesized derivatives were then purified and elucidated for their structure by measuring their melting points, infra-red spectra and proton NMR spectra. The progress of the reaction was determined by using thin layer chromatography technique. The antimicrobial potential of the synthesized derivatives was evaluated against S. aureus and E. coli. The zone of inhibition (mm) was measured. Reported derivatives showed good to moderate antibacterial activity

Year 2022 | Volume No. 59 | Issue No.1 | Page No. 23-27
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