Table of Contents

March  2023

  • Volume 60
  • Issue 3
  • Page Nos. 96

ISSN: 0019-462X (print)

Editorial

COLLABORATIVE INNOVATION - A TOOL FOR WASTE DISPOSAL AND RECYLING

PAGE 5-6

Dear Reader,

The Pharmaceutical industry is the most controlled industry and remains on top of the list with the most regulatory controls through multiple Acts and Rules. Many of the regulations are specific to Pharmaceuticals industry among other governing all others industries, in gener...

Dr. Gopakumar G. Nair

Editor

Indian Drugs

Review Article

ARUNDO DONAX L.: A SCIENTIFIC UPDATE

PAGE 7-16

Arundo donax L. belongs to the family Poaceae. It has been found in the Mediterranean, North Africa, India and Pakistan. It grows in hilly locations in India. It grows up to 2100-2440 m in the Himalayas. Commonly, A. donax L. is known as Giant Reed in English and Narakata in Hindi. Traditionally ...

Kapil Sachana *, Amrendra K. Chaudharyb, Shamim Ahmadc and K. Nagarajana

Original Research Articles

SYNTHESIS, CHARACTERIZATION, IN VITRO ANTIMICROBIAL AND ANTIINFLAMMATORY EVALUATIONS OF {5’-(SUBSTITUTED ARYL)-2-FURANYL}-3,4- DIHYDRO-1H-PYRIMIDINE-2-ONE DERIVATIVES

PAGE 17-29

In the present study, a series of 5’-(substituted aryl)-2-furanyl}-3,4-dihydro-1H-pyrimidine-2-ones has been designed and synthesized with Beginelli reaction derivatives carried out from the reaction of ethyl acetoacetate 1 with substituted ureas 2 and substituted aryl furfuraldehydes 3 in pres...

Munendra M. Varshneya , Pooja A. Chawlab*, Ghanshyam Telib and Asif Hussainc

DESIGN AND DEVELOPMENT OF DOLUTEGRAVIR SODIUM CO-CRYSTALS LOADED ORODISPERSIBLE TABLET WITH IMPROVED DISSOLUTION BEHAVIOUR

PAGE 30-39

The current research work was aimed at improving the solubility of dolutegravir sodium (BCS class II) by utilizing the approach of co-crystallization and formulating orodispersible tablets of chosen cocrystals to maximize the therapeutic use of dolutegravir sodium. Co-crystals were prepared by th...

Paul B. Rodriquesa,c and Bhupendra G. Prajapatib*

PHYTOCHEMISTRY AND ANTIBACTERIAL ACTIVITY OF TRADITIONAL MEDICINAL PLANT ZIZIPHUS RUGOSA LAM.

PAGE 40-46

Ziziphus rugosa Lam. a member of the Rhamnaceae family, is found in the semi-evergreen forests of the Western Ghat region, India. This plant is used in many traditional formulations owing to its benefits in miscarriage, misconception, syphilis, tachycardia, diarrhea, flatulence, dropsy, skin dise...

Sushma Gaikwada and Tabassum Khanb*

METHOD DEVELOPMENT AND VALIDATION FOR THE ANALYSIS OF DOLUTEGRAVIR IN PURE AND DOSAGE FORMS USING ULTRAVIOLET-VISIBLE SPECTROSCOPY

PAGE 47-52

A colorimetric method for the analysis of dolutegravir in pure form and in tablets has been developed based on the formation of green colour complex. The method is based on the diazotization of carbonyl group and coupling with 3-methyl-2-benzothiazolinone hydrazone reagent in presence of ferric c...

Sheeja Velayudhankuttya *, Shamla Moideena , Swapna A. Surendrana , Akhil M. Babua and Nihila Kasima

POLYMORPHIC STABILITY EVALUATION OF DARUNAVIR AND RITONAVIR IN FIXED DOSE DRUG COMBINATION PRODUCT BY X-RAY DIFFRACTION AND DIFFERENTIAL SCANNING CALORIMETRY TECHNIQUES

PAGE 53-63

Evaluation of polymorphism for active ingredients and its stability during manufacturing and storage is a critical task for pharmaceutical firms. For solubility enhancement of ritonavir, hot melt extrusion process was selected through conversion of commercially available crystalline form to amorp...

Munish K. Bucha,b* and Hasit V. Vaghanic

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF RELATED SUBSTANCES AND PURITY OF FAVIPIRAVIR DRUG SUBSTANCE

PAGE 64-80

Favipiravir (6-fluoro-3-hydroxy-2-pyrazine carboxamide) is an antiviral drug that specifically and potently inhibits the RNA-dependent RNA polymerase enzyme of RNA viruses. A straightforward stabilityindicating high-performance liquid chromatography (RP-HPLC) approach can be used to identify favi...

Manoj A. Mangukiyaa,b, Pritam V. Bagweb, Aman A. Desaia and Shreerang V. Joshib*

ANTI-ARTHRITIC ACTIVITY OF ETHANOLIC EXTRACT OF CITRUS AURANTIUM LINN. LEAVES IN COMPLETE FREUND’S ADJUVANT INDUCED ARTHRITIS IN RATS

PAGE 81-88

The present research work was carried out to evaluate the anti-arthritic activity of ethanolic extract of leaves of Citrus aurantium Linn. on Complete Freund’s adjuvant (CFA)-induced arthritis model in rats. Dried leaves powder was extracted and coded as ECA (ethanolic extract of C. aurantium)....

Bhagyabhumi P. Shaha *, Nikita A. Patelb and Samir K. Shahc

Short Communications

PROTECTIVE EFFECT OF PORTULACA QUADRIFIDA ON ROTENONE INDUCED MITOCHONDRIAL DYSFUNCTION IN RAT BRAIN SYNAPTOSOMES

PAGE 89-91

Mitochondrial dysfunction as a virtue of oxidative stress leads to neurodegeneration. The neurotoxin rotenone, is widely used to induce mitochondrial dysfunction and hence evaluate the neuroprotective action of a sample drug. For this study and comparison, the hexane extract, chloroform extract, ...

Swati Dhandea * and Vijay Patilb

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