Table of Contents

May  2022

  • Volume 59
  • Issue 5
  • Page Nos. 84

Editorial

PHARMA RESEARCH IN INDIA & ROLE OF CSIR LABORATORIES AND SCIENCE EDUCATION IN INDIA

PAGE 5-6

Dear Reader,

It is indeed heartening to note that Dr. D. Srinivasa Reddy, who has close research and professional connections with IDMA and other Pharma Associations and has received Awards also from Industry, has joined the Indian Institute of Chemical Technology (IICT), Hyderabad as the...

Dr. Gopakumar G. Nair

Editor

Indian Drugs

Review Article

PHOSPHODIESTERASE (PDE) INHIBITORS IN ALZHEIMER’S DISEASE: ROLE AND CURRENT STATUS

PAGE 7-16

Alzheimer’s disease is a progressive neurodegenerative disease, usually associated with old age. With the increasing geriatric population throughout the world, it will pose a great socio-economic burden on the healthcare system and the caregivers. The clinically approved drugs for management of...

Kajal Jadejaa , Mihir P. Khambetea * and Tabassum A. Khana

Original Research Articles

2D QSAR STUDIES OF NOVEL TRIAZOLINONE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS USING TOPOLOGICAL DESCRIPTORS

PAGE 17-23

Quantitative Structure Activity Relationship (QSAR) model on a series of triazolinone derivatives acting as angiotensin II receptor using partial least squares regression analysis was performed to compute the relationship with 2D structure descriptors. The computational studies were performed wit...

Mukesh C. Sharmaa * and D. V. Kohlib

FORMULATION DEVELOPMENT OF DICLOFENAC SODIUM LOTION USING MIXED SOLVENCY CONCEPT AND IN VITRO EVALUATION

PAGE 24-30

The concept of mixed solvency is an emerging field which can serve as a new method for solubility enhancement and therefore deserves urgent attention of the scientific community to assess its efficiency and applicability. Mixed solvency concept suggests that each substance present on the earth wh...

Anirudh Padiyara * and Rajesh K. Maheshwaria

QUALITY ASSESSMENT OF SOME MARKETED HEPATOPROTECTIVE POLYHERBAL FORMULATIONS

PAGE 31-39

The present study was proposed for assessing the variation in quality of some hepatoprotective polyherbal products that are widely available in the market. Different brands of marketed hepatoprotective formulations were evaluated in the present investigation with respect to qualitative analysis b...

Rajendra O. Ganjiwalea *, Pramod G. Yeoleb and Dilesh J. Singhavic

ADVANCED HPLC METHOD DEVELOPMENT, VALIDATION AND FORCE DEGRADATION STUDY FOR SIMULTANEOUS ANALYSIS OF ALLANTOIN, HYDROQUINONE AND TRETENOIN IN MELASMA TOPICAL CREAM FORMATION

PAGE 40-47

A simple, sensitive, rapid, precise and accurate RP-HPLC method has been developed for simultaneous estimation of hydroquinone, allantoin and tretinoin from cream formulation. Chromatographic separation was achieved on a reversed-phase Inertsil C18 (4.6 mm) I.D.× 250 mm, 5 µm) column...

Raksha Shiluab* and Pankaj Kapuparaa

A NOVEL VALIDATED STABILITY INDICATING ANALYTICAL METHOD FOR QUANTIFICATION OF EMPAGLIFLOZIN IN BULK AND MARKETED FORMULATION BY RP-HPLC APPLYING EXPERIMENTAL DESIGN APPROACH

PAGE 48-57

A stability indicating reversed-phase high-performance liquid-chromatographic method for analysis of empagliflozin was developed and validated as per the ICH guidelines. Statistical design of experiment was applied for optimization, where independent variables used were methanol proportions in mo...

Manojkumar K. Mundea,b*, Nilesh S. Kulkarnib, Nikita B. Rukheb, Ashim K. Sena and Dhanya B. Sena

A NOVEL VALIDATED BIO-ANALYTICAL METHOD DEVELOPMENT for AZELNIDIPINE (DIHYDROPYRIDINE) IN INDIAN HUMAN PLASMA BY LIQUID CHROMATOGRAPHY QUADRUPLE TANDEM MASS SPECTROMETRY (LC-ESI-MS/MS, API-4000) WITH AN APPLICATION TO IN VIVO PHARMACOKINETIC AND BIOEQUIVA

PAGE 58-70

Azelnidipine is a dihydropyridine used as a calcium channel blocker. The main aim of this study was to develop a validated bio-analytical method (as per US-FDA and EMA guidelines) for in vivo pharmacokinetic and bioequivalence study of azelnidipine in human plasma by LC-MS/MS, API-4000. In this m...

Pallab Mandala , Soumya Chakrabortya , Rakesh Beraa , Chiranjit Sahaa , Tapan K. Pala *, Balaram Ghoshb and Sourav Poddarc

Short Communications

PREPARATION AND EVALUATION OF CHITOSAN CAPSULE FOR COLON SPECIFIC DELIVERY OF CAPECITABINE

PAGE 71-74

The prime objective of the present study was to develop enteric coated chitosan capsule containing capecitabine for targeting colorectal cancer cells. The study describes a new colonic drug delivery system utilizing capsule shells prepared from chitosan. Coating of drug filled chitosan capsule wi...

Akshata S. Gavadea *, Dheeraj S. Randivea , Mangesh A. Bhutkara , Somnath D. Bhingeb, Asha M. Jagtapa and Ganesh B.Vambhurkara

SIMULTANEOUS ANALYSIS OF EZETIMIBE AND ROSUVASTATIN BY UV SPECTROPHOTOMETRIC METHOD

PAGE 75-76

A novel UV spectrophotometric method has been developed for the simultaneous estimation of ezetimibe and rosuvastatin in combined dosage form. Method is based on simultaneous equations method. The wavelengths selected for analysis were λmax of ezetimibe: 231.2 nm and λmax ...

Pratiksha Nagvenkara , Celina Nazaretha * and Salina Fernandesa

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