Hepatic afflictions continue to pose serious challenges in therapy. The liver exhibits different types of cells, mainly, kupffer cells, sinusoidal endothelial cells, stellate cells and pit cells which represent reticuloendothelial systems. hepatocytes are the non-reticuloendothelial system. While...
Gastroretentive drug delivery systems are designed to prolong the gastric residence time after oral administration, at specific site and controlling the release of drug, especially being useful for achieving controlled plasma level as well as improving bioavailability. In the present work, gastro...
The objective of the study was to investigate the biodistribution behavior of a fluorescent marker encapsulated in polymeric colloidal nanoparticulate system comprised of PLGA [poly (lactide-co-glycolic acid)] and also to quantify the uptake of fluorescein sodium by brain following intra nasal ad...
Hydrogels are 3-dimensional hydrophilic polymeric networks composed of homo or co-polymers capable of imbibing large amounts of biological fluids. They can be tailored as modified release dosage forms for both hydrophilic and hydrophobic drugs. The present study was aimed to develop and character...
Curcumin, a yellow polyphenolic component obtained from the plants of the Curcuma longa, has been used traditionaly as a therapeutic agent. curcumin has poor bioavailability. This problem can be overcome by using nanoparticle technology using biocompatible chitosan as an encapsulating polymer for...
Withaferin A, a steroidal lactone which is present in dry root extract of Withania somnifera (WSE), is reported to possess numerous pharmacological activities and shows poor aqueous solubility. The purpose of this study is to enhance the dissolution rate and oral bioavailability of WSE by incorpo...