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While India has acquired global recognition as a reliable source of high quality, impurity free active pharmaceutical ingredients (APIs) and generic pharmaceuticals, Indian pharmaceutical R&D has to go a long way to enter the global pharmaceutical R&D map. The 2016 OE...

A convenient and efficient reaction of chalcone for the synthesis of highly functionalized pyrazole and pyridine has been developed. Many pieces of evidence point out the relevance of natural compounds for malaria and its prevention, including chalcones. Ring substituted quinolines are synthesize...

A new series of substituted benzimidazole derivatives was synthesis and the structures of these compounds were established on the basis of spectral data. The title compounds were evaluated for in vitro anticancer activity against MCF - 7 and NCI-H226 cell line. Some of these compounds have shown ...

A quantitative structure activity relationship study was performed on a series of pyridine substituted compounds as angiotensin II receptors for establishing quantitative relationship between biological activity and their physicochemical structural properties. Partial least square (PLS) methodolo...

Artemisia annua L. (Asteraceae) is an aromatic annual herb, up to 2 m in height, found in temperate Asia, especially China and naturalized in many countries of the world. The plant is prescribed against fever, malaria, skin diseases, jaundice, malignant ulcers and haemorrhoids. Phytochem...

The study was planned to investigate the anti-urolithiatic activity of fresh juice of Citrus limon L. fruit. The phytochemical screening was also undertaken to reveal the alkaloids, flavonoids, reducing sugar, vitamin C, amino acid and sterols present in the sample. Macromolecule supersaturation ...

The present work was undertaken with the aim to develop and validate a rapid and consistent RP-HPLC method in which the peaks will be appear with short period of time as per ICH Guidelines. The separation was achieved on a Kromosil -ODS C18 (250 X 4.6 mm; 5 μ) column in an isocratic mode. The mo...

This research paper dealt with chemometric optimization for HPLC analysis of simultaneous determination of the nucleotide tenofovir (TFV) and nucleoside emtricitabine (FTC) reverse transcriptase inhibitors in human plasma. Central composite design and Derringer’s desirability function were used...

In the present study, an attempt has been made to develop an analytical method for the simultaneous estimation of gallic acid and embelin in marketed Ayurvedic polyherbal formulation Avipathi choornam by High Performance Liquid Chromatography (HPLC). The chromatographic separation was performed o...

This study evaluated the antioxidant, hypoglycemic, antidiabetic and alpha amylase inhibiting activities of Sargassum wightii. Antioxidant activity of ethyl acetate and methanol extracts of this seaweed was evaluated and extract having promising antioxidant activity was further studied for hypogl...

Adverse drug reactions (ADR) are the leading cause for the hospital administration, morbidity, and mortality as per the established data. Present pharmacovigilance program of India is performing well for strengthening ADR reporting system. The current project is aimed to study knowledge, attitude...

The objective of the present investigation was to formulate multiparticulate buoyant dosage form of nizatidine, a H2-receptor antagonist widely prescribed in gastric ulcers, duodenal ulcers. The short biological half-life (1 -2 hours), maximum absorption in initial part of small intestine, coloni...