Articles Accepted

The current research focuses on the formulation and evaluation of a Garlic Oil:Nirgundi Oil-loaded nanoemulsion intended for topical delivery. A 2³ full factorial design was employed to optimize the formulation variables, including concentrations of Tween 80, PEG 400, and oil (Garlic Oil:Nirgundi Oil). Preformulation studies confirmed the identity and compatibility of the drug and excipients using boiling point analysis and FTIR spectroscopy. Eight nanoemulsion batches (F1–F8) were prepared, among which formulation F3 exhibited the most promising characteristics. F3 showed a mean droplet size of 112.4 nm, polydispersity index of 0.209, and zeta potential of –30.96 mV, confirming its nanoscale uniformity and stability. TEM analysis revealed spherical droplets with smooth surfaces. The pH (6.98), viscosity profile, and absence of phase separation indicated suitability for skin application and physical stability. In-vitro drug release studies validated sustained release, with F3 achieving 98.84 ± 2.59% and 98.45±2.56 release over 8 hours. Three-month accelerated studies confirmed that the garlic-nirgundi oil nanoemulsion (F3) is a stable, and effective carrier for drug delivery.