Articles Accepted

Current work aimed to use liquisolid compact technology to build a pulsating carvedilol system. Core tablets were produced, with a Syloid 244FP coating and a Neusillin US2 carrier. In-vivo investigations were carried out to see how the core tablets affected the blood pressure of rats in which hypertension was induced. The tablets were press-coated with a barrier layer made of the polymers HPMC K 15M and ethyl cellulose. The physical characteristics of the liquisolid-based pulsatile formulations produced were investigated using differential scanning calorimetry, X-ray diffraction analysis, and infrared spectroscopic techniques. Compared with a commercial formulation, optimized liquisolid core-tablets reduced the blood pressure significantly (P0.0001). The lag time of the tablets with the optimized composition was 6 hours. The carvedilol release within a lag time of 1 hour was 100.002 percent. Our findings suggest that carvedilol was effectively delivered in the desired pulsatile release pattern by the liquisolid compact-based compression-coated tablets.