Articles Accepted

Mebendazole (MBZ), an anthelmintic used for treating parasitic worm infections, was incorporated into nanosponges to improve its delivery. The nanosponges were prepared using polyvinyl alcohol (PVA) as an emulsifying agent and ethylene cellulose as a polymer via emulsion solvent diffusion. The formulation was optimized using Central Composite Design (CCD) and evaluated for various physicochemical properties, including production yield, entrapment efficiency, FTIR, DSC, FESEM, PXRD, particle size, zeta potential, and in-vitro release.The production yield was 91.21%, and entrapment efficiency was 89.13%. Characterization confirmed successful encapsulation and nanosponge formation.FESEM showed porous, spherical structures, and the zeta potential was +11.2 mV, with a particle size of 554 nm. The in-vitro drug release was 86.66%, and capsule disintegration and drug content tests were successful.Stability studies indicated the capsules were stable.These results suggest that mebendazole-loaded nanosponges effectively address challenges associated with conventional MBZ formulations.