Articles Accepted

Fabrication and Characterization of Centrifugal Spun Ciprofloxacin-Loaded Microfiber Dressing for the Treatment of Diabetic Foot Ulcers
by Mr. Shaikh Mohd Fareed, 02 Oct 2023
Co-Author(s): Payaam Aslam Vohra,Jaya Agnihotri

Open sores or wounds on the feet with a bony prominence are commonly known as Diabetic Foot Ulcers (DFUs). They are a common complication of uncontrolled diabetes mellitus and can be dangerous as they increase the risk of Infection. DFUs typically take longer to heal, sometimes resulting in severe complications such as amputation. Our study aimed to develop a drug delivery system that could help manage DFUs. We used polymer-based fibers that were loaded with Ciprofloxacin-HCl to create this system. The optimized polymeric fiber batch demonstrated over 90% drug entrapment, controlled drug release for 72 hours, an average fiber diameter of 4.88 μm, and porosity above 70%. We also found that the drug-loaded fibers exhibited antimicrobial activity against gram-negative (E. coli) and gram-positive (S. aureus) pathogens commonly found in DFUs. Additionally, the fibers were highly compatible with blood components, ensuring excellent hemocompatibility. Our study's findings show great potential in managing DFUs, and future studies will explore the potential application of this drug delivery system in treating and managing diabetic foot ulcers.

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