Articles Accepted

Solubility enhancement technique for BCS class II drug - Ondansetron hydrochloride by co-crystallization method
by Mrs. Pratiksha Akki, 14 Jul 2023
Co-Author(s): Rohan Latwade,Pratiksha Akki,Kusum Akki

Objective: The present study is aimed to increase solubility of ondansetron hydrochloride by preparing cocrystals via co crystallization method using various coformers. Method: The Cocrystals of ondansetron HCL were prepared using coformer such as benzoic acid aspirin, benzamide, PABA, Urea and Citric acid by Solvent evaporation method The prepared Co-crystals were evaluated for solubility, and dissolution rate. The Co-crystals were characterized by The Co-crystals were characterized by. The Co-crystals were characterized by, FT-Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and powder X-ray Diffractometry (PXRD), scanning electronic Microscopy (SEM) Results: The solubility of ondansetron HCL -benzoic acid Cocrystals (17.8740.35), ondansetron HCL-aspirin Cocrystals (14.11+0.20) and ondansetron HCL-benzamide Cocrystals (5.1540.23), ondansetron HCL-PABA cocrystals (6.38+0.5),ondanstron-Urea crystals(7.9140.11), and ondansetron HCL-Citric acid co crystals (9.11±0.26) was significantly higher than that of pure ondansetron HCI, (0.347-0.06). dissolution rate of Cocrystals reported percentage drug release at 30 min is 99.36%,97,08%,63,60%,70.98% 78.70% and 79.54% with Benzoic acid, Aspirin, Benzamide, PABA, Urea and Citric acid respectively compared with pure ondansetron HCL 38.70% within 30 min. The Fourier transform infrared spectroscopy indicated a shift in the characteristic peaks of the cocrystals, but did not suggest any interaction between the coformer. Differential scanning calorimetry data showed a change in the endotherm, resulting in a new melting point of the cocrystals. the X-ray diffraction spectra demonstrated a difference in the 20 and the intensity of the peaks finallyThe scanning electron microscopy of both pure ondansetron HCL and its co crystals showed the formation of a different solid phase with the presence of the co formers

Current Issue
Quick Contact