Articles Accepted

ESTIMATION OF RESVERATROL AND GLABRIDIN IN GEL FORMULATION BY UV SPECTROSCOPY
by Dr. Tabassum Khan, 22 Mar 2024
Co-Author(s): Mayur S Wagh

Acne and hyperpigmentation are the most common problems in adolescents globally. Resveratrol and glabridin are proven to be effective against acne hyperpigmentation. We developed a gel comprising of these two actives for acne and hyperpigmentation treatment. This research project is aimed to establish and validate a reliable and rapid spectroscopic method for the simultaneous determination of resveratrol and glabridin, exhibiting high precision and accuracy. UV spectral analysis indicated 306nm and 281nm to be the λmax for resveratrol and glabridin respectively in methanol. The method validation was done as per ICH guidelines Q2 R1. The linearity studies conducted in methanol and phosphate buffer pH 7.4 resulted in a correlation coefficient (r2) of 0.99. The validated method was applied to assay the developed gel for resveratrol and glabridin content, demonstrating the suitability of this UV spectroscopic method for simultaneous quantification and can be applied for other delivery systems.

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