Articles Accepted

Designing, Development and Evaluation of Gastroretentive Floating Tablet Case Employing Fused Deposition Modeling (FDM) 3D Printing Technology
by Dr. Kuldeep Vinchurkar, 26 Jan 2024

This research focuses on the exploration of an innovative Fused Deposition Model (FDM) 3D Printing Method for fabricating a gastroretentive floating tablet case containing metronidazole compressed tablets. Metronidazole served as the model drug and was successfully incorporated into a floating tablet case comprised of Polyvinyl Alcohol Filament. The tablet design, generated using AutoCAD software, underwent slicing to produce three distinct batches, each optimized with various orifice sizes. The 3D printed tablet cases were systematically evaluated for weight variation, friability, hardness, in-vitro floating performance, and in-vitro dissolution characteristics. All outcomes conformed to acceptable standards. Notably, the tablet case with a 0.5 mm orifice exhibited a remarkable floatation duration of over 345 minutes on the surface of 0.1 N HCl media, showcasing a zero-order drug release profile. This study underscores the potential of 3D Printing technology as an innovative platform for the development of gastroretentive floating tablets, ushering in a contemporary era of personalized medicine.

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