Articles Accepted

FORMULATION AND EVALUATION OF NANOSTRUCTURED LIPID CARRIERS BASED CAPSULE
by Dr. Dhanashree, 23 Jan 2024
Co-Author(s): Karan K Lokhande,Pranali P Malusare,Dhanashree P Sanap,Kisan R Jadhav

The aim of this study was to develop an optimal nanostructured lipid carrier (NLC) for glibenclamide in oral capsules. Employing factorial design, the NLC formulation was achieved through high-pressure homogenization using Design Expert software, optimized using a 32-factor experimental design and response surface analysis. Comprehensive analyses of particle size, zeta potential, drug entrapment efficiency, and in vitro drug release were conducted to characterize the NLCs and determine the optimal formulation. Rigorous evaluations, including drug content, in vitro diffusion, and stability studies, were performed. Safety assessments, efficacy studies, and optimization led to the identification of an optimal NLC formulation with specific lipid and surfactant percentages, resulting in a desirable particle size (nm) and a robust zeta potential indicative of strong physical stability.

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