Articles Accepted

ESTABLISHMENT AND AUTHENTICATION OF A UV SPECTROPHOTOMETRIC APPROACH FOR MEASURING EMBELIN CONTENT IN BULK AND FORMULATED SAMPLE
by Dr. Dhanashree, 28 Dec 2023
Co-Author(s): Kritika Saboo,Rohit Ghadge,Dhanashree Prakash Sanap,Sneha Agrawal

The UV-spectrophotometric method for the estimation of embelin isolated from Embelia ribes berriers as per ICH guidelines Q2 (R1). For the estimation of embelin, a simple, quick, accurate, and affordable UV-spectrophotometric method has been developed. The wavelength of embelin was found to be 294.3 nm; and was linear in the concentration range 2-12 μg/ml; 0.997 correlation coefficient. The method was applied to pharmaceutical formulation and drug estimated was found to be 97.99 % and was in good term with the label claim. The accuracy of the method was performed at three different levels, in between 80 to 120 %; with % recovery obtained 98.54 - 99.98 %. The low values of % RSD indicate that the method is accurate and reproducible. Interday, intraday variations and repeatability was studied as precision parameters. Lower % RSD value than 2 indicates developed method is precise. Ruggedness of the proposed method was studied with the aid of two analysts.

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December 2023
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