Articles Accepted

by Dr. Sachin Namdeo Kothawade, 28 Nov 2022
Co-Author(s): Vishal Vijay Pande

The use of microemulsion as a delivery system for improving take - up across nasal mucosa is currently being studied. A mucoadhesive polymer is added to help extend the retention time on the mucosa. Due to their biocompatibility, biodegradability, simplicity in preparation and handling, and most importantly, their ability to solubilize both water- and oil-soluble drugs, microemulsions have garnered a lot of attention in recent years. The primary goal of the current research was to create a nanoformulation of amisulpride also with intention of increasing the drug's permeability and protecting it with a biocompatible lipid content, avoid first pass metabolism and efflux mechanisms, and select the route of administration to deliver Amisulpride to brain/ CNS in order to increase the bioavailability of Amisulpride at targeted site of Schizophrenia. For calculating the percentage of transmittance, the in vitro release profile, and for estimating the levels of amisulpride in the brain and plasma, appropriate analytical methods were chosen, developed, and validated. The result revealed that residence time of ME was enhanced by mucoadhesive agent and targeted site of action were achieved.

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