Articles Accepted

PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF LITSEA GHATICA STEM BARK
by Dr. Tabassum Khan, 10 Aug 2022
Co-Author(s): Deepika Tiwari

Litsea belonging to family Lauraceae is among the most diverse genera of evergreen shrubs and trees. Litsea is distributed majorly in the Western Ghats of India. Litsea and they are traditionally used to treat cold, fever, bruises, insect bites and other disease conditions The objective of this study was to study the phytochemical of the methanol extract of Litsea ghatica stem bark and evaluate it for potential antioxidant activity in an effort to understand the nature of phytoconstituents present in the stem bark. Phytochemical screening of the methanol extract indicated the presence of phenols, flavonoids, tannins, saponins and carbohydrates. The total phenolic and flavonoid content in the methanol extract was determined by Folin Ciocalteau’s and aluminium chloride method respectively. The antioxidant activity of the methanol extract was evaluated by 2,2-Diphenyl-1-picrylhydrazyl (DPPH), Ferric reducing antioxidant power (FRAP) and NO scavenging radical assays. The methanol extract showed significant potential antioxidant activity, 93.08 & 95.1 % radical scavenging activity in DPPH assay at 100 ppm for the methanol extract and ascorbic acid respectively. In FRAP and NO radical scavenging assay, the methanol extract showed dose dependent antioxidant activity reaching maximum at 100 ppm concentration. The anti-inflammatory activity of the methanol extract was determined by in vitro albumin denaturation study using naproxen as the reference standard. The results indicated significant anti-inflammatory activity of the methanol extract with 18.53% inhibition at 60 ppm concentration.

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