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During the turn of the century and early millennium, when the potential of online pharmacies was predicted, there was widespread hue and cry including the regulators.The regulator agencies had cautioned against any proposal for online selling of medicines and had declared suc...

Lipids are present abundantly in human body in several forms. Different types of lipids are available with diverse physical properties, based on which suitable lipids can be selected for development of formulations. Lipids are also available for specific purposes like lubrication, emulsification,...

A total of 12 substituted naphthoic acid-linked imidazothiadiazole derivatives were synthesized and evaluated for their anticancer potential against human lung cancer cell line A-549 and also for their antimicrobial activity by measuring zone of inhibition (mm) against S. aureus, B. subtilis and ...

Diacerein (DCN), an anti- inflammatory, anti-osteoarthritic drug having short-acting properties was formulated as microsphere following fluid bed bottom spray coating technique for sustained release drug delivery, where HPMC (6cps) and ethyl cellulose (N7) were used as coating polymers. Assay of ...

Colchicine is an alkaloid which has been reported to possess anti-gout, anti-rheumatic, antiparasitic and anticancer potential. It is a toxic natural product obtained from plants of the genus Colchicum (C. autumnale and C. luteum), Gloriosa superba, and Iphigenia indica. In the present study, thr...

Double Divisor ratio spectra derivative method was developed and validated for a ternary mixture containing abacavir sulphate (ABA), lamivudine (LAM) and dolutegravir sodium (DOL) in distilled water. The method is based on dividing the absorption spectra of ternary mixture by the sum of absorptio...

A simple HPLC method was developed for the simultaneous estimation of saxagliptin and dapagliflozin in rat plasma. The separation has been achieved by C₈ Eclipse plus column (25cm x 5cm x 4.6µ) at 1 mL min^-1 flow rate. The mobile phase comprises of 0.01 % trimethylamine in ...

A simple, precise, reproducible and sensitive RP HPLC method was developed and validated for the quantification of exemestane (EXM) in nanoemulsion. The method was developed using Phenomenex C₁₈ column (250 mm × 4.6 mm i.d., 5 µm) and acetonitrile: methanol (40:60 V/V) was used as mo...

Hepatocellular carcinoma (HCC) is constantly seeking the interest of researchers as an untreatable and fatal disease, attaining second position so far worldwide. Our study provides us an opportunity to explore new potential therapeutic combinations in this regard. We hypothesized that the antican...

The objective of this study was to focus on the antiviral activity of a bile salt, namely sodium deoxycholate. There is a possibility of killing severe acute respiratory syndrome corona virus-2 due to the destruction of its protein and lipid overcoat by sodium deoxycholate alone or with drugs tho...

The objective of the present work was to formulate and evaluate bilayer tablets of alogliptin and metformin HCl. Combining alogliptin with metformin HCL gives additional benefits in comparison with either drug alone and could be considered for patients whose quality of life is impaired by diabete...