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Grant of patent is largely based on the prior and clear understanding of the patentability criteria more by the inventors than the applicants. Any perceived invention must meet the basic requirements of novelty and inventive steps. Novelty is easy to target as it requires ...

Improving the treatment of neurodegenerative disorders such as Parkinson’s (PD) and Alzheimer’s disease (AD) has always been challenging. Compared with oral drug administration, nasal mucosa has emerged as a convenient target tissue for drug delivery because of its accessibility, high blood ...

Compound (9Z, 12Z)-octadeca-9, 12-dienoic acid (CGHY 02) was isolated from Coccinia grandis (L.) Voigt n-butanol extract by column chromatography. A molecular docking study against human pancreatic alpha-amylase enzyme (PDB: 3OLE) yielded a good docking score of -112.37 Kcal mol-1, indicating a ...

Periodontitis is one of the most widespread oral inflammatory infectious diseases affecting the oral cavity. This study aims to develop and characterize a more effective syringeable curcumin in situ gel for the treatment of periodontitis and evaluate its clinical effectiveness. Curcumin in situ ...

Today, there is a growing demand for natural antioxidants. The unbalanced production and consumption of reactive oxygen species cause many disorders such as cancer, arteriosclerosis, Alzheimer’s disease and aging. For this purpose, the present study was a part of the in vitro evaluation of the ...

Forced degradation studies in tablet and bulk formulations of remogliflozin etabonate have been developed using a precise and sensitive high performance thin layer chromatographic method. The silica gel RP-18 F254S plates were used as the stationary phase and ACN: water: ammonia solution (8:2:0.5...

The goal of the study was to provide an overview of the technique development and validation of a stability-indicating HPLC approach for routine analysis of besifloxacin hydrochloride in pharmaceutical product (ophthalmic suspension). HPLC method was development on octadecasilyl silica (C18, 250 ...

A novel, sensitive, stability-indicating gradient RP-HPLC method has been developed for simultaneous estimation of clobazam and its related substances in oral suspension. The chromatographic separation of degradation products and matrix components was executed on a YMC Pack ODS-A column with ...

New stability indicating RP-HPLC method for the simultaneous estimation of sofosbuvir and daclatasvir in its pharmaceutical dosage form was developed and validated. Column used was PhenomenexC18 (150mm x 4.6mm, 5µ) with mobile phase water and acetonitrile (50:50 V/V) in isocratic mode. Flow rate...

The antidiabetic activity of Coptis teeta extract (CE) was investigated in a diabetic rat model. Alloxan (150 mg kg-1, i.p.) was used to induce hyperglycemia in rats. Oral administration of CE at the dose of 250 and 500 mg kg-1 for 28 days lowered the blood glucose level. Various physical ...

This study aimed to expand the trouble-free, quick, cost-effective and sensitive 1st Order derivative spectroscopy method for bendamustine hydrochloride.The aliquot was scanned from 200-400 nm using blank methanol as a solvent and the absorption was recorded. The stored spectrum was modified into...

A comparative evaluation of solid lipid nanoparticles and solid dispersion of bicalutamide using PVP K30 and stearic acid was performed. Bicalutamide solid dispersions (BL- SD) were prepared with conventional solvent evaporation method and bicalutamide solid lipid nanoparticles (BL-SLN) were ...