Medicinal Natural Products Research Laboratory Department of Pharmaceutical Sciences and Technology Institute of Chemical Technology Nathalal Parikh Marg Matunga, Mumbai- 400019, India.
*E-mail: galvinaferr@gmail.com
https://doi.org/10.53879/id.50.10.p0062
ABSTRACT
A series of alkyl derivatives of plumbagin (2-methyl-5-hydroxy-1,4-naphthoquinone), analogous to Vitamin K, have been synthesized. Plumbagin reacts with carboxylic acid in presence of silver nitrate and ammonium peroxydisulphate to form its alkyl derivatives. The compounds synthesized were characterized by MS, IR, 1 H and 13C-NMR Spectroscopy. The derivatives prepared may find application as antithrombotic agents and may facilitate designing of similar newer analogues.
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