ABSTRACT

The research emphasizes the formulation development and evaluation of a polyherbal effervescent antidiabetic powder by incorporating Syzygium cumini (Jamun seeds), Pterocarpus marsupium (Vijaysar wood), and Withania coagulans (Paneer phool). These herbs were selected for their traditional antidiabetic properties and potential synergistic effects. The powder was prepared using a dry mixing method to ensure the stability of moisture-sensitive ingredients like sodium bicarbonate, citric acid and tartaric acid, which facilitate rapid effervescence. Evaluation revealed excellent flow properties and a rapid effervescence time of approximately 90 sec. In vitro analysis via an α-amylase inhibition assay confirmed significant antidiabetic activity, with 72.9% inhibition at 75 mg mL-1. The formulation offers a patient-friendly, fast-acting alternative for diabetes management.