ABSTRACT

This study presents a novel nanotherapeutic strategy for the treatment of arthritis utilising copper nanoparticles prepared using leaf extract from Baliospermum solanifolium. Known for its antiinflammatory properties, the plant was used as a natural capping and reducing agent during the development of nanoparticles. Fourier Transform Infrared spectroscopy, XRD, SEM, and UV-Vis spectroscopy were utilized to thoroughly evaluate the size, shape and structural integrity of the greensynthesised copper nanoparticles. The anti-inflammatory qualities were assessed in vivo using a carrageenan paw oedema model in rats. The copper nanoparticle gel formulation showed significantly superior anti-arthritic activity. These results suggest that a topical gel containing copper nanoparticles derived from B. solanifolium provides a safe and efficient nanotherapeutic alternative for the treatment of arthritis symptoms, with promising potential.