ABSTRACT

A simple, precise and stability-indicating first-order derivative UV spectrophotometric method was developed for the estimation of maribavir in the presence of its acid hydrolysis degradation products. Maribavir is an antiviral agent used in the treatment of cytomegalovirus (CMV) infections, especially in transplant recipients. Chromatographic (HPLC & HPTLC) methods failed to resolve the drug peak from that of degradants. Hence UV method was optimized by selecting 260.6 nm, the zero crossing wavelength of the degradant, allowing selective quantification of maribavir without interference. Linearity was observed over the range of 10–60 µg mL-1 with an excellent correlation coefficient (R² = 0.998). The method was validated according to ICH Q2(R2) guidelines.