ABSTRACT

Pityriasis capitis commonly known as dandruff, is an un-inflamed or mildly inflamed form of seborrheic dermatitis and appears as bran-like scaly patches scattered within hair bearing areas of the scalp and which could result in scaly itchy skin of the scalp. The present research work was carried out to develop tampoo. Tampoo is a novel solid dosage antidandruff formulation loaded with ketoconazole, prepared by direct compression technique having ease of manufacturability, improved stability and which becomes shampoo after aqueous dispersion, the moment it comes in contact with water. The combination of elastic and plastic materials, viz gaur gum and dibasic calcium phosphate in appropriate proportions was used to compress poorly compressible sodium lauryl sulphate. Tapmoos were compressed using direct compression method and evaluated for effect of filler binder, foam booster and disintegrating agents. Based on the results obtained, it was found that formulation F6 containing surface active agent (sodium lauryl sulphate) and foam booster (gaur gum) imparts acceptable pharmaceutical properties.