ABSTRACT

Oral drug delivery is the most popular method of control and release of therapeutic agents for the management of diseases. The colon specific drug delivery systems are considered to attain targeted drug delivery to the large intestine specifically at colon. They provide local delivery for the treatment of colonic diseases like inflammatory bowel disease. The present investigation is based on response of percent drug release as dependent variable for the study at Y axis with two different variables-concentration of surfactant (X1) and stirring speed (X2). A 3² full factorial design was used for complete reading of blending of polymers. The effects of surfactant concentration and stirring speed were evaluated by different parameters as entrapment efficiency, particle size, surface characteristics, micromeritic properties, DSC study and in vitro drug release studies. The present investigation reveals that galactomannan gum containing microspheres are promising as a carrier for colon targeted delivery of ciprofloxacin.