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For decades the Indian Pharmaceutical Industry has proudly worn the mantle of the “Pharmacy of the World” driven by an unparalleled mastery of small molecules, using efficient manufacturing and chemical synthesis. However, as the global therapeutic landscape rapidly shift...

Numerous pharmacological characteristics, such as antioxidant, anti-inflammatory, antibacterial, antidiabetic, anticancer, cholesterol lowering, wound healing, cardioprotective and neuroprotective actions, are displayed by ferulic acid (FA), a crucial hydroxycinnamic acid found in plant cell wall...

The current study investigates the in silico molecular interaction behavior of octanoic acid derived from the metabolite of a marine bacterium against targeted bacterial virulence factors and cancer-associated protein structures. Liquid Chromatography-Tandem Mass Spectrometry analysis was carried...

This study focuses on optimizing the dry granulation process for cefditoren pivoxil tablets (400 mg) to enhance their dissolution performance, addressing the challenges posed by the drug’s high insolubility (BCS Class IV). Using a Quality by Design approach [QbD] and Response Surface Methodolog...

The effectiveness of betulinic acid in anti-inflammation has been demonstrated. However, the role of betulinic acid in inhibition of zymosan-stimulated inflammation in macrophages remains unclear. Therefore, this study aimed to investigate the effects of betulinic acid from Adenosma caeruleum R.B...

Valbenazine tosylate is a drug indicated for the management of tardive dyskinesia. This study presents the optimization of chromatographic methods to assess the inherent stability of this molecule. The stability studies were executed as per the ICH guidelines, integrating multiple stress conditio...

Irritable bowel syndrome (IBS) is a gastrointestinal disorder marked by abdominal pain, bloating, and altered bowel habits, affecting 4.2%-7.5% of the Indian population. The constipation-predominant subtype (IBS-C) poses significant management challenges, prompting interest in alternative therapi...

The study aimed to enhance the dissolution and bioavailability of efavirenz, a BCS Class II drug, through solid dispersions (SDs) using PEG 4000 and Gelucire® 44/14 as hydrophilic carriers. The Gibbs free energy values (ΔGo tr) were negative, and decreased with increasing carrier concentration....