Table of Contents

June  2024

  • Volume 61
  • Issue 6
  • Page Nos. 86

ISSN (Print) : 0019-462X

Guest Editorial

WHY TARGET AYURVEDIC DRUGS FOR DRUG INDUCED LIVER INJURY (DILI)?

PAGE 5-6

Dear Reader,

Use of herbs as medicines is as old as history of human civilization. Discovery of most of the modern medicines dates back to 19th and 20th century. Most of the potent drugs discovered have their origin in plants and they were also called “Drugs from P...

Dr. Chandra Kant Katiyar

Advisor, R&D Healthcare, Emami Ltd.

Review Article

A REVIEW ON MICROSPHEREs: TYPES, METHODS AND EVALUATION

PAGE 7-20

Controlled drug delivery system (CDDS) allows active pharmaceutical agent (API) to be released over extended periods of time, ranging from days to months, by using drug-encapsulating devices. Such systems have a number of merits over conventional drug delivery techniques, including the ability to...

Darsh Gautama,c* and Poonam Talwanb,c

Original Research Articles

IN SILICO DESIGNING AND SCREENING OF CARBAZOLE DERIVATIVES AS TOPOISOMERASE II INHIBITORS

PAGE 21-37

Due to side effects and drug resistance, cancer treatment choices are limited despite continued attempts. Topoisomerases are essential for several cellular processes and human topoisomerase I and topoisomerase II alpha inhibitors have proven to be an effective chemotherapeutic alternative for a w...

Elseena Josea *, Prasanth Francisa , Mariya Joya , Shilpa Josepha , Sunitha Sukumarana and Sini Babya

DESIGN, FORMULATION AND EVALUATION OF PIROXICAM TABLETs USING ARTIFICIAL NEURAL NETWORK

PAGE 38-43

In the realm of pharmaceuticals, artificial intelligence (AI) denotes the application of automated algorithms to tasks traditionally associated with human cognitive abilities. An artificial neural network (ANN) serves as a simulation of the human brain, aiming to replicate both the structure and ...

Pratiksha Akkia *, Apoorva V. a and Kusum S. Akkib

DEVELOPMENT AND EVALUATION OF PHARMACEUTICALLY EQUIVALENT LEVOSALBUTAMOL DRY POWDER INHALER WITH INCREASED IN VITRO DEPOSITION

PAGE 44-52

The advancement and assessment of an efficient and safe dry powder inhaler formulation for levosalbutamol are critical for optimizing its therapeutic potential in managing chronic obstructive pulmonary disease (COPD). This study aims to provide an overview of the development process and evaluatio...

Suraj L. Dongarea *, Minal R. Narkhedea and Prachiti S. Rathoda

INTEGRATIVE ANALYSIS OF MORINGA OLEIFERA PHYTOCHEMICAL COMPOSITION: INSIGHTS FROM LCMS/MS, HPTLC, HPLC PROFILING AND MOLECULAR DOCKING STUDIES

PAGE 53-62

This research presents a comprehensive investigation into the phytochemical composition of Moringa oleifera utilizing LCMS/MS, HPTLC, HPLC profiling and molecular docking studies. LCMS/MS analysis identified 10 key phytocompounds, including β-carbolines, octadecadiynoic acid and quercetin. HPLC ...

Shital Neherea * and Kiran Bhisea

IN VIVO EVALUATION OF CURCUMIN REVEALs BIPHASIC ANGIOGENESis ACTIVITY IN ZEBRAFISH EXPERIMENTAL MODEL

PAGE 63-69

Curcumin, a prominent polyphenol compound present in Curcumin longa L., exhibits diverse pharmacological and biological effects. Its hydrophobic nature and poor bioavailability necessitate its solubilization in an amphiphilic solvent such as dimethyl sulfoxide (DMSO) for research purpose. The pre...

Priyanka P. Nigadea , Ketaki V. Gurava , Utkarsha Pawara and Vandana S. Nikama *

Short Communications

FORCE DEGRADATION AND STABILITY STUDY OF 7-HYDROXY COUMARIN

PAGE 70-73

The research investigates the stability of 7-hydroxy coumarin i.e. umbelliferone, a compound with diverse applications, through forced degradation studies under various conditions. These investigations aim to comprehend its susceptibility to degradation and provide insights crucial for its safe h...

Sneha Agrawala *, Sagarika Dhamne and Pradum Shindea

COMPARATIVE IN SILICO MOLECULAR DOCKING ANALYSIS OF SOPHOCARPINE AND CHELERYTHRINE ALKALOIDS FOR ANTIHERPES ACTIVITY

PAGE 74-76

Herpes infection is considered a global health burden. Developing new therapeutic strategies for treating herpes is a challenging research problem. This study aimed to investigate and compare the potential antiviral activity of Sophocarpine and Chelerythrine alkaloids against Herpes Simplex Virus...

Thomas Kuriana *

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