Articles Accepted

Aim: Cimetidine is an anti-ulcer medication that is used orally. This study aimed to create a gastro-retentive in-situ gel containing the medication with the goal of increasing its oral bio-availability and providing prolonged release of the medication. Method: Cimetidine floating in-situ gel was prepared by using diverse polymers like Xanthan gum, sodium alginate, gellan gum by incorporating emulsion into the polymeric solution which leads to floating in-situ gel. The prepared solution was assessed for pH, viscosity, drug content and in-vitro drug release studies. Through DSC and FTIR investigations, the compatibility of drugs with excipients was verified. Stability study of the formulation was done at room temperature for the period of 3 months. Results: Drug-polymer interaction studies (FTIR and DSC) displayed compatibility between the drug and polymer. In- vitro drug release studies presented good drug release in the range of 61.64% to 84.4% over a period of 10 hours. The best formulation was found to be F4 that is showing in-vitro drug release of 68.64%. The correlation coefficient (R2) values attained from the kinetic equations shows that the drug release from all the formulations (F1 to F9) follow Higuchi first order drug release mechanism. Conclusion: The approved formulations satisfied all requirements to create an in-situ gel system that was gastro retentive and quickly gelled and floated in the stomach's pH range. Therefore, it may be concluded that the stomach-specific in-situ forming gel of cimetidine may be a more cost-efficient and effective formulation than traditional formulations due to its improved efficacy, delayed release, and patient compliance.