Articles Accepted

In the present investigation, amoxicillin loaded mucoadhesive microsphere were prepared and characterized. The prepared formulation was optimized using two factorial three level central composite experimental design employing response surface methodology. Drug loading (%), and concentration of HPMC (%) were chosen as independent variable. The response yield and drug release were selected as dependable variable. The characterization of fabricated microspheres was conducted by FTIR, scanning electron microscopy (SEM), entrapment efficiency, and particle size was analyzed. The wash out test and mucoadhesive test of prepared formulations were also carried out. SEM studies revealed the surface smoothness of fabricated microspheres. Further, in-vitro release study of preparations was conducted and the results were best fitted into Higuchi kinetic model. The percentage yield and drug release from optimized batch was found to exist 72.08 and 85.53 respectively