Articles Accepted

Purpose: Blood glucose lowering effect of endocarp of Cocos nucifera was studied in female albino wistar rats. Oral Glucose Tolerance Test (OGTT) study is performed for the coconut oil and dried water extracts of Cocos nucifera with metformin solution as the standard. Method: OGTT study was performed and the blood glucose time-level shows that, in control administered group an elevation in blood glucose level after administration of glucose solution and then normalized back to within fasting blood glucose level by physiological mechanisms. Result: Analyzing the results of study, upon administration of control the BGL rises from 67mg/dl to 166.25mg/dl. That is at 30th minute, 98.5 mg/dl difference exist, whereas in STD, this difference is 61.75mg/dl, which implies that the drug might have enhanced the clearance of glucose. After administration of coconut oil BGL falls to a value that lies in range of 59-74mg/dl Conclusion: Result shows that the drug may be able to maintain a normal glycemic level without causing significant hypoglycemic effect. Coconut extract is reducing the absorption of glucose from GIT, or enhancing the distribution of glucose into tissues thereby reducing the BGL. All the test samples reduced BGL within 4-7% by 90 minutes after drug was given. Test drugs have the capacity to absorb glucose molecules to cell.