Articles Accepted

ADVANCES IN TARGETED DRUG DELIVERY SYSTEM: AN OUTLINE
by Dr. Mohammed Misbah Ul Haq, 14 Jul 2021
Co-Author(s): Mohd Munaf Ur Razzak,Mohd Arif Uddin,Nazish Ahmed,SM Shahidulla

Targeted drug delivery system, also known as smart drug delivery, is a method of treatment that involves the increase in medicament in one or a few body parts compared to others. Two strategies are used for the drug targeting to the desired organ/tissue: passive targeting and active targeting. Drug delivery vehicles transport the drug either within or in the site of the target. An idealistic drug delivery vehicle is supposed to cross even stubborn sites such as a blood-brain barrier. In drug delivery systems such as oral or intravascular administration, the drug is distributed all over the body through the systemic blood flow. For most therapeutic agents, only a small part of the drug reaches the affected organ. For example, in chemotherapy, about 99% of the administered drug does not reach the tumor site. The present review of targeted drug delivery attempts to focus on the drug in the tissue of absorption while lowering the relative dose of the drug in the remaining tissues. By avoiding the host's defence mechanisms and inhibiting non-specific distribution in the liver and spleen, a device may enter the intended site of action in higher concentrations. It has been discovered that targeted delivery increases effectiveness while reducing side effects. The drug properties, side-effects of the medications, the route of administration for drug delivery, the intended location, and finally the disease must all be considered when developing a targeted release system.

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