Articles Accepted

Study of Post Shelf Life and Marketed Tablets of Carvedilol By RP-HPLC
by Dr. Sailesh, 10 Jul 2021
Co-Author(s): Shailesh Jayantilal Wadher,Rupali Balasaheb Giri

The objective of the current study was to determine the tablet content and carry out the dissolution test of expired and non-expired tablet and develop simple, selective, linear, precise, accurate and sensitive RP-HPLC method was developed and validated of Carvedilol tablet. Experiment was run with 20 mM PB pH 2.5: ACN (55:45) v/v mobile phase at pH 2.5 using column (Oyster ODS 3,150-4.6mm,5µm,) L6 6AD pump. 20ul of sample is injected at ambient temperature for 6 min run time with a flow rate of 1.0 ml/min and detection were identified at 240 nm by UV detector. The sample retention time is 3.1 min. The initial dissolution tests were carried out on Electro lab dissolution tester at 37o c ±0.5. Results of this investigation showed that the drug content didn’t change significantly. The % assay was found to be of non-expired tablet was 94.67% and expired tablet was 91.71%.

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